human adult brain unamplified cdna library (Edge Biosystems Inc)
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human adult brain unamplified cdna library
Human Adult Brain Unamplified Cdna Library, supplied by Edge Biosystems Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+adult+brain+unamplified+cdna+library/human+adult+brain+unamplified+cdna+library/pm35501530-75-39-49
Average 90 stars, based on 1 article reviews
Human Adult Brain Unamplified Cdna Library, supplied by Edge Biosystems Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/human+adult+brain+unamplified+cdna+library/human+adult+brain+unamplified+cdna+library/pm35501530-75-39-49
Average 90 stars, based on 1 article reviews
human adult brain unamplified cdna library - by Bioz Stars,
2026-09
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Expressing:Article Title: Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia. Article Snippet: mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of GPS-1 (Genebank accession no. BC064503; nucleotide coding region 1396-1602), Ajuba (BC007580; 114-1354), JWA (NM006407; 181- 520), KIAA0302 (AB008567; 5958-6345), and ARHGEF11 (NM014784; 1935-2309), from a Article Title: Expression of Transcripts for Myelination-Related Genes in the Anterior Cingulate Cortex in Schizophrenia Article Snippet: The sensitivity and reproducibility of in situ hybridization has previously been well characterized ( Williams, 1982 ; Downs and Williams, 1984 ; Stolz et al., 1989 ). mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Abbreviation: CNP, Genebank accession number: NM_03313, region used for probe: 523–1066), myelin-associated glycoprotein (MAG, XM_01287, 305–835), transferrin (TF, XM_00279, 1172–1940), quaking (QKI, {"type":"entrez-nucleotide","attrs":{"text":"AF142421","term_id":"7542354","term_text":"AF142421"}} AF142421 , 508–715), gelsolin (GSN, XM_01654, 1249–1649), myelin oligodendrocyte glycoprotein (MOG, {"type":"entrez-nucleotide","attrs":{"text":"U18800","term_id":"62177688","term_text":"U18800"}} U18800 , 109–263), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3, NM_00198, 3081–3325), erbb2 interacting protein (ErbB2IP, NM_01869, 3531–3858), motility-related protein-1 (CD9, {"type":"entrez-nucleotide","attrs":{"text":"M38690","term_id":"1048988","term_text":"M38690"}} M38690 , 330–666), SRY-box containing gene 10 (SOX10, BL007595, 1337–1560), oligodendrocyte transcription factor 2 (OLIG2, NM_00580, 423–628), peripheral myelin protein 22 (PMP22, {"type":"entrez-nucleotide","attrs":{"text":"BC019040","term_id":"33874197","term_text":"BC019040"}} BC019040 , 293–637), and Claudin-11 (CLDN11, NM_00560, 610–821) from a Article Title: Expression of Transcripts for Myelination-Related Genes in the Anterior Cingulate Cortex in Schizophrenia Article Snippet: Subject Characteristics In situ hybridization The sensitivity and reproducibility of in situ hybridization has previously been well characterized ( Williams, 1982 ; Downs and Williams, 1984 ; Stolz et al., 1989 ). mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Abbreviation: CNP, Genebank accession number: NM_03313, region used for probe: 523–1066), myelin-associated glycoprotein (MAG, XM_01287, 305–835), transferrin (TF, XM_00279, 1172–1940), quaking (QKI, {"type":"entrez-nucleotide","attrs":{"text":"AF142421","term_id":"7542354","term_text":"AF142421"}} AF142421 , 508–715), gelsolin (GSN, XM_01654, 1249–1649), myelin oligodendrocyte glycoprotein (MOG, {"type":"entrez-nucleotide","attrs":{"text":"U18800","term_id":"62177688","term_text":"U18800"}} U18800 , 109–263), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3, NM_00198, 3081–3325), erbb2 interacting protein (ErbB2IP, NM_01869, 3531–3858), motility-related protein-1 (CD9, {"type":"entrez-nucleotide","attrs":{"text":"M38690","term_id":"1048988","term_text":"M38690"}} M38690 , 330–666), SRY-box containing gene 10 (SOX10, BL007595, 1337–1560), oligodendrocyte transcription factor 2 (OLIG2, NM_00580, 423–628), peripheral myelin protein 22 (PMP22, {"type":"entrez-nucleotide","attrs":{"text":"BC019040","term_id":"33874197","term_text":"BC019040"}} BC019040 , 293–637), and Claudin-11 (CLDN11, NM_00560, 610–821) from a Article Title: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy Article Snippet: In Situ Hybridization Subclones for riboprobe synthesis were prepared by amplifying unique regions of GS and PAG from a Article Title: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy Article Snippet: Subclones for riboprobe synthesis were prepared by amplifying unique regions of GS and PAG from a Article Title: Differential genetic associations and expression of PAPST1/SLC35B2 in bipolar disorder and schizophrenia. Article Snippet: Lithium’s inhibitory effect on enzymes involved in sulfation process, such as inhibition of 3’(2’)-phosphoadenosine 5’-phosphate (PAP) phosphatase, is a possible mechanism of its therapeutic effect for bipolar disorder (BD).. 3’-Phosphoadenosine 5’-phosphosulfate (PAPS) is translocated from cytosol to Golgi lumen by PAPS transporter 1 (PAPST1/SLC35B2), where it acts as a sulfa donor.. Since SLC35B2 was previously recognized as a molecule that facilitates the release of D-serine, a co-agonist of N-methyl-D-aspartate type glutamate receptor, altered function of SLC35B2 might be associated with the pathophysiology of BD and schizophrenia (SCZ). Article Title: Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia. Article Snippet: Numerous molecules enable the handling of glutamate that is destined for neurotransmitter release, including transporters, receptors and glutamatergic enzymes.. Previous work in our lab has shown altered levels of transcript expression of excitatory amino acid transporters and a vesicular glutamate transporter in the thalamus in schizophrenia.. These changes suggest that molecules that facilitate the release and reuptake of glutamate may be abnormal in schizophrenia. In Situ Hybridization:Article Title: Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia. Article Snippet: mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of GPS-1 (Genebank accession no. BC064503; nucleotide coding region 1396-1602), Ajuba (BC007580; 114-1354), JWA (NM006407; 181- 520), KIAA0302 (AB008567; 5958-6345), and ARHGEF11 (NM014784; 1935-2309), from a Article Title: Expression of Transcripts for Myelination-Related Genes in the Anterior Cingulate Cortex in Schizophrenia Article Snippet: The sensitivity and reproducibility of in situ hybridization has previously been well characterized ( Williams, 1982 ; Downs and Williams, 1984 ; Stolz et al., 1989 ). mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Abbreviation: CNP, Genebank accession number: NM_03313, region used for probe: 523–1066), myelin-associated glycoprotein (MAG, XM_01287, 305–835), transferrin (TF, XM_00279, 1172–1940), quaking (QKI, {"type":"entrez-nucleotide","attrs":{"text":"AF142421","term_id":"7542354","term_text":"AF142421"}} AF142421 , 508–715), gelsolin (GSN, XM_01654, 1249–1649), myelin oligodendrocyte glycoprotein (MOG, {"type":"entrez-nucleotide","attrs":{"text":"U18800","term_id":"62177688","term_text":"U18800"}} U18800 , 109–263), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3, NM_00198, 3081–3325), erbb2 interacting protein (ErbB2IP, NM_01869, 3531–3858), motility-related protein-1 (CD9, {"type":"entrez-nucleotide","attrs":{"text":"M38690","term_id":"1048988","term_text":"M38690"}} M38690 , 330–666), SRY-box containing gene 10 (SOX10, BL007595, 1337–1560), oligodendrocyte transcription factor 2 (OLIG2, NM_00580, 423–628), peripheral myelin protein 22 (PMP22, {"type":"entrez-nucleotide","attrs":{"text":"BC019040","term_id":"33874197","term_text":"BC019040"}} BC019040 , 293–637), and Claudin-11 (CLDN11, NM_00560, 610–821) from a Article Title: Expression of Transcripts for Myelination-Related Genes in the Anterior Cingulate Cortex in Schizophrenia Article Snippet: Subject Characteristics In situ hybridization The sensitivity and reproducibility of in situ hybridization has previously been well characterized ( Williams, 1982 ; Downs and Williams, 1984 ; Stolz et al., 1989 ). mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Abbreviation: CNP, Genebank accession number: NM_03313, region used for probe: 523–1066), myelin-associated glycoprotein (MAG, XM_01287, 305–835), transferrin (TF, XM_00279, 1172–1940), quaking (QKI, {"type":"entrez-nucleotide","attrs":{"text":"AF142421","term_id":"7542354","term_text":"AF142421"}} AF142421 , 508–715), gelsolin (GSN, XM_01654, 1249–1649), myelin oligodendrocyte glycoprotein (MOG, {"type":"entrez-nucleotide","attrs":{"text":"U18800","term_id":"62177688","term_text":"U18800"}} U18800 , 109–263), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3, NM_00198, 3081–3325), erbb2 interacting protein (ErbB2IP, NM_01869, 3531–3858), motility-related protein-1 (CD9, {"type":"entrez-nucleotide","attrs":{"text":"M38690","term_id":"1048988","term_text":"M38690"}} M38690 , 330–666), SRY-box containing gene 10 (SOX10, BL007595, 1337–1560), oligodendrocyte transcription factor 2 (OLIG2, NM_00580, 423–628), peripheral myelin protein 22 (PMP22, {"type":"entrez-nucleotide","attrs":{"text":"BC019040","term_id":"33874197","term_text":"BC019040"}} BC019040 , 293–637), and Claudin-11 (CLDN11, NM_00560, 610–821) from a Article Title: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy Article Snippet: In Situ Hybridization Subclones for riboprobe synthesis were prepared by amplifying unique regions of GS and PAG from a Article Title: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy Article Snippet: Subclones for riboprobe synthesis were prepared by amplifying unique regions of GS and PAG from a Article Title: Differential genetic associations and expression of PAPST1/SLC35B2 in bipolar disorder and schizophrenia. Article Snippet: Lithium’s inhibitory effect on enzymes involved in sulfation process, such as inhibition of 3’(2’)-phosphoadenosine 5’-phosphate (PAP) phosphatase, is a possible mechanism of its therapeutic effect for bipolar disorder (BD).. 3’-Phosphoadenosine 5’-phosphosulfate (PAPS) is translocated from cytosol to Golgi lumen by PAPS transporter 1 (PAPST1/SLC35B2), where it acts as a sulfa donor.. Since SLC35B2 was previously recognized as a molecule that facilitates the release of D-serine, a co-agonist of N-methyl-D-aspartate type glutamate receptor, altered function of SLC35B2 might be associated with the pathophysiology of BD and schizophrenia (SCZ). Article Title: Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia. Article Snippet: Numerous molecules enable the handling of glutamate that is destined for neurotransmitter release, including transporters, receptors and glutamatergic enzymes.. Previous work in our lab has shown altered levels of transcript expression of excitatory amino acid transporters and a vesicular glutamate transporter in the thalamus in schizophrenia.. These changes suggest that molecules that facilitate the release and reuptake of glutamate may be abnormal in schizophrenia. Generated:Article Title: Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia. Article Snippet: mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of GPS-1 (Genebank accession no. BC064503; nucleotide coding region 1396-1602), Ajuba (BC007580; 114-1354), JWA (NM006407; 181- 520), KIAA0302 (AB008567; 5958-6345), and ARHGEF11 (NM014784; 1935-2309), from a Article Title: Expression of Transcripts for Myelination-Related Genes in the Anterior Cingulate Cortex in Schizophrenia Article Snippet: The sensitivity and reproducibility of in situ hybridization has previously been well characterized ( Williams, 1982 ; Downs and Williams, 1984 ; Stolz et al., 1989 ). mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Abbreviation: CNP, Genebank accession number: NM_03313, region used for probe: 523–1066), myelin-associated glycoprotein (MAG, XM_01287, 305–835), transferrin (TF, XM_00279, 1172–1940), quaking (QKI, {"type":"entrez-nucleotide","attrs":{"text":"AF142421","term_id":"7542354","term_text":"AF142421"}} AF142421 , 508–715), gelsolin (GSN, XM_01654, 1249–1649), myelin oligodendrocyte glycoprotein (MOG, {"type":"entrez-nucleotide","attrs":{"text":"U18800","term_id":"62177688","term_text":"U18800"}} U18800 , 109–263), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3, NM_00198, 3081–3325), erbb2 interacting protein (ErbB2IP, NM_01869, 3531–3858), motility-related protein-1 (CD9, {"type":"entrez-nucleotide","attrs":{"text":"M38690","term_id":"1048988","term_text":"M38690"}} M38690 , 330–666), SRY-box containing gene 10 (SOX10, BL007595, 1337–1560), oligodendrocyte transcription factor 2 (OLIG2, NM_00580, 423–628), peripheral myelin protein 22 (PMP22, {"type":"entrez-nucleotide","attrs":{"text":"BC019040","term_id":"33874197","term_text":"BC019040"}} BC019040 , 293–637), and Claudin-11 (CLDN11, NM_00560, 610–821) from a Article Title: Expression of Transcripts for Myelination-Related Genes in the Anterior Cingulate Cortex in Schizophrenia Article Snippet: Subject Characteristics In situ hybridization The sensitivity and reproducibility of in situ hybridization has previously been well characterized ( Williams, 1982 ; Downs and Williams, 1984 ; Stolz et al., 1989 ). mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Abbreviation: CNP, Genebank accession number: NM_03313, region used for probe: 523–1066), myelin-associated glycoprotein (MAG, XM_01287, 305–835), transferrin (TF, XM_00279, 1172–1940), quaking (QKI, {"type":"entrez-nucleotide","attrs":{"text":"AF142421","term_id":"7542354","term_text":"AF142421"}} AF142421 , 508–715), gelsolin (GSN, XM_01654, 1249–1649), myelin oligodendrocyte glycoprotein (MOG, {"type":"entrez-nucleotide","attrs":{"text":"U18800","term_id":"62177688","term_text":"U18800"}} U18800 , 109–263), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3, NM_00198, 3081–3325), erbb2 interacting protein (ErbB2IP, NM_01869, 3531–3858), motility-related protein-1 (CD9, {"type":"entrez-nucleotide","attrs":{"text":"M38690","term_id":"1048988","term_text":"M38690"}} M38690 , 330–666), SRY-box containing gene 10 (SOX10, BL007595, 1337–1560), oligodendrocyte transcription factor 2 (OLIG2, NM_00580, 423–628), peripheral myelin protein 22 (PMP22, {"type":"entrez-nucleotide","attrs":{"text":"BC019040","term_id":"33874197","term_text":"BC019040"}} BC019040 , 293–637), and Claudin-11 (CLDN11, NM_00560, 610–821) from a Article Title: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy Article Snippet: In Situ Hybridization Subclones for riboprobe synthesis were prepared by amplifying unique regions of GS and PAG from a Article Title: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy Article Snippet: Subclones for riboprobe synthesis were prepared by amplifying unique regions of GS and PAG from a Article Title: Differential genetic associations and expression of PAPST1/SLC35B2 in bipolar disorder and schizophrenia. Article Snippet: Lithium’s inhibitory effect on enzymes involved in sulfation process, such as inhibition of 3’(2’)-phosphoadenosine 5’-phosphate (PAP) phosphatase, is a possible mechanism of its therapeutic effect for bipolar disorder (BD).. 3’-Phosphoadenosine 5’-phosphosulfate (PAPS) is translocated from cytosol to Golgi lumen by PAPS transporter 1 (PAPST1/SLC35B2), where it acts as a sulfa donor.. Since SLC35B2 was previously recognized as a molecule that facilitates the release of D-serine, a co-agonist of N-methyl-D-aspartate type glutamate receptor, altered function of SLC35B2 might be associated with the pathophysiology of BD and schizophrenia (SCZ). Article Title: Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia. Article Snippet: Numerous molecules enable the handling of glutamate that is destined for neurotransmitter release, including transporters, receptors and glutamatergic enzymes.. Previous work in our lab has shown altered levels of transcript expression of excitatory amino acid transporters and a vesicular glutamate transporter in the thalamus in schizophrenia.. These changes suggest that molecules that facilitate the release and reuptake of glutamate may be abnormal in schizophrenia. cDNA Library Assay:Article Title: Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia. Article Snippet: mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of GPS-1 (Genebank accession no. BC064503; nucleotide coding region 1396-1602), Ajuba (BC007580; 114-1354), JWA (NM006407; 181- 520), KIAA0302 (AB008567; 5958-6345), and ARHGEF11 (NM014784; 1935-2309), from a Article Title: Expression of Transcripts for Myelination-Related Genes in the Anterior Cingulate Cortex in Schizophrenia Article Snippet: The sensitivity and reproducibility of in situ hybridization has previously been well characterized ( Williams, 1982 ; Downs and Williams, 1984 ; Stolz et al., 1989 ). mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Abbreviation: CNP, Genebank accession number: NM_03313, region used for probe: 523–1066), myelin-associated glycoprotein (MAG, XM_01287, 305–835), transferrin (TF, XM_00279, 1172–1940), quaking (QKI, {"type":"entrez-nucleotide","attrs":{"text":"AF142421","term_id":"7542354","term_text":"AF142421"}} AF142421 , 508–715), gelsolin (GSN, XM_01654, 1249–1649), myelin oligodendrocyte glycoprotein (MOG, {"type":"entrez-nucleotide","attrs":{"text":"U18800","term_id":"62177688","term_text":"U18800"}} U18800 , 109–263), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3, NM_00198, 3081–3325), erbb2 interacting protein (ErbB2IP, NM_01869, 3531–3858), motility-related protein-1 (CD9, {"type":"entrez-nucleotide","attrs":{"text":"M38690","term_id":"1048988","term_text":"M38690"}} M38690 , 330–666), SRY-box containing gene 10 (SOX10, BL007595, 1337–1560), oligodendrocyte transcription factor 2 (OLIG2, NM_00580, 423–628), peripheral myelin protein 22 (PMP22, {"type":"entrez-nucleotide","attrs":{"text":"BC019040","term_id":"33874197","term_text":"BC019040"}} BC019040 , 293–637), and Claudin-11 (CLDN11, NM_00560, 610–821) from a Article Title: Expression of Transcripts for Myelination-Related Genes in the Anterior Cingulate Cortex in Schizophrenia Article Snippet: Subject Characteristics In situ hybridization The sensitivity and reproducibility of in situ hybridization has previously been well characterized ( Williams, 1982 ; Downs and Williams, 1984 ; Stolz et al., 1989 ). mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Abbreviation: CNP, Genebank accession number: NM_03313, region used for probe: 523–1066), myelin-associated glycoprotein (MAG, XM_01287, 305–835), transferrin (TF, XM_00279, 1172–1940), quaking (QKI, {"type":"entrez-nucleotide","attrs":{"text":"AF142421","term_id":"7542354","term_text":"AF142421"}} AF142421 , 508–715), gelsolin (GSN, XM_01654, 1249–1649), myelin oligodendrocyte glycoprotein (MOG, {"type":"entrez-nucleotide","attrs":{"text":"U18800","term_id":"62177688","term_text":"U18800"}} U18800 , 109–263), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3, NM_00198, 3081–3325), erbb2 interacting protein (ErbB2IP, NM_01869, 3531–3858), motility-related protein-1 (CD9, {"type":"entrez-nucleotide","attrs":{"text":"M38690","term_id":"1048988","term_text":"M38690"}} M38690 , 330–666), SRY-box containing gene 10 (SOX10, BL007595, 1337–1560), oligodendrocyte transcription factor 2 (OLIG2, NM_00580, 423–628), peripheral myelin protein 22 (PMP22, {"type":"entrez-nucleotide","attrs":{"text":"BC019040","term_id":"33874197","term_text":"BC019040"}} BC019040 , 293–637), and Claudin-11 (CLDN11, NM_00560, 610–821) from a Article Title: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy Article Snippet: In Situ Hybridization Subclones for riboprobe synthesis were prepared by amplifying unique regions of GS and PAG from a Article Title: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy Article Snippet: Subclones for riboprobe synthesis were prepared by amplifying unique regions of GS and PAG from a Article Title: Differential genetic associations and expression of PAPST1/SLC35B2 in bipolar disorder and schizophrenia. Article Snippet: Lithium’s inhibitory effect on enzymes involved in sulfation process, such as inhibition of 3’(2’)-phosphoadenosine 5’-phosphate (PAP) phosphatase, is a possible mechanism of its therapeutic effect for bipolar disorder (BD).. 3’-Phosphoadenosine 5’-phosphosulfate (PAPS) is translocated from cytosol to Golgi lumen by PAPS transporter 1 (PAPST1/SLC35B2), where it acts as a sulfa donor.. Since SLC35B2 was previously recognized as a molecule that facilitates the release of D-serine, a co-agonist of N-methyl-D-aspartate type glutamate receptor, altered function of SLC35B2 might be associated with the pathophysiology of BD and schizophrenia (SCZ). Article Title: Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia. Article Snippet: Numerous molecules enable the handling of glutamate that is destined for neurotransmitter release, including transporters, receptors and glutamatergic enzymes.. Previous work in our lab has shown altered levels of transcript expression of excitatory amino acid transporters and a vesicular glutamate transporter in the thalamus in schizophrenia.. These changes suggest that molecules that facilitate the release and reuptake of glutamate may be abnormal in schizophrenia. Polymerase Chain Reaction:Article Title: Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia. Article Snippet: mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of GPS-1 (Genebank accession no. BC064503; nucleotide coding region 1396-1602), Ajuba (BC007580; 114-1354), JWA (NM006407; 181- 520), KIAA0302 (AB008567; 5958-6345), and ARHGEF11 (NM014784; 1935-2309), from a Article Title: Expression of Transcripts for Myelination-Related Genes in the Anterior Cingulate Cortex in Schizophrenia Article Snippet: The sensitivity and reproducibility of in situ hybridization has previously been well characterized ( Williams, 1982 ; Downs and Williams, 1984 ; Stolz et al., 1989 ). mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Abbreviation: CNP, Genebank accession number: NM_03313, region used for probe: 523–1066), myelin-associated glycoprotein (MAG, XM_01287, 305–835), transferrin (TF, XM_00279, 1172–1940), quaking (QKI, {"type":"entrez-nucleotide","attrs":{"text":"AF142421","term_id":"7542354","term_text":"AF142421"}} AF142421 , 508–715), gelsolin (GSN, XM_01654, 1249–1649), myelin oligodendrocyte glycoprotein (MOG, {"type":"entrez-nucleotide","attrs":{"text":"U18800","term_id":"62177688","term_text":"U18800"}} U18800 , 109–263), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3, NM_00198, 3081–3325), erbb2 interacting protein (ErbB2IP, NM_01869, 3531–3858), motility-related protein-1 (CD9, {"type":"entrez-nucleotide","attrs":{"text":"M38690","term_id":"1048988","term_text":"M38690"}} M38690 , 330–666), SRY-box containing gene 10 (SOX10, BL007595, 1337–1560), oligodendrocyte transcription factor 2 (OLIG2, NM_00580, 423–628), peripheral myelin protein 22 (PMP22, {"type":"entrez-nucleotide","attrs":{"text":"BC019040","term_id":"33874197","term_text":"BC019040"}} BC019040 , 293–637), and Claudin-11 (CLDN11, NM_00560, 610–821) from a Article Title: Expression of Transcripts for Myelination-Related Genes in the Anterior Cingulate Cortex in Schizophrenia Article Snippet: Subject Characteristics In situ hybridization The sensitivity and reproducibility of in situ hybridization has previously been well characterized ( Williams, 1982 ; Downs and Williams, 1984 ; Stolz et al., 1989 ). mRNA expression was measured by in situ hybridization using subclones that were generated by amplifying unique segments of 2′,3′-cyclic nucleotide 3′-phosphodiesterase (Abbreviation: CNP, Genebank accession number: NM_03313, region used for probe: 523–1066), myelin-associated glycoprotein (MAG, XM_01287, 305–835), transferrin (TF, XM_00279, 1172–1940), quaking (QKI, {"type":"entrez-nucleotide","attrs":{"text":"AF142421","term_id":"7542354","term_text":"AF142421"}} AF142421 , 508–715), gelsolin (GSN, XM_01654, 1249–1649), myelin oligodendrocyte glycoprotein (MOG, {"type":"entrez-nucleotide","attrs":{"text":"U18800","term_id":"62177688","term_text":"U18800"}} U18800 , 109–263), v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (ErbB3, NM_00198, 3081–3325), erbb2 interacting protein (ErbB2IP, NM_01869, 3531–3858), motility-related protein-1 (CD9, {"type":"entrez-nucleotide","attrs":{"text":"M38690","term_id":"1048988","term_text":"M38690"}} M38690 , 330–666), SRY-box containing gene 10 (SOX10, BL007595, 1337–1560), oligodendrocyte transcription factor 2 (OLIG2, NM_00580, 423–628), peripheral myelin protein 22 (PMP22, {"type":"entrez-nucleotide","attrs":{"text":"BC019040","term_id":"33874197","term_text":"BC019040"}} BC019040 , 293–637), and Claudin-11 (CLDN11, NM_00560, 610–821) from a Article Title: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy Article Snippet: In Situ Hybridization Subclones for riboprobe synthesis were prepared by amplifying unique regions of GS and PAG from a Article Title: Gene Expression of Glutamate Metabolizing Enzymes in the Hippocampal Formation in Human Temporal Lobe Epilepsy Article Snippet: Subclones for riboprobe synthesis were prepared by amplifying unique regions of GS and PAG from a Article Title: Differential genetic associations and expression of PAPST1/SLC35B2 in bipolar disorder and schizophrenia. Article Snippet: Lithium’s inhibitory effect on enzymes involved in sulfation process, such as inhibition of 3’(2’)-phosphoadenosine 5’-phosphate (PAP) phosphatase, is a possible mechanism of its therapeutic effect for bipolar disorder (BD).. 3’-Phosphoadenosine 5’-phosphosulfate (PAPS) is translocated from cytosol to Golgi lumen by PAPS transporter 1 (PAPST1/SLC35B2), where it acts as a sulfa donor.. Since SLC35B2 was previously recognized as a molecule that facilitates the release of D-serine, a co-agonist of N-methyl-D-aspartate type glutamate receptor, altered function of SLC35B2 might be associated with the pathophysiology of BD and schizophrenia (SCZ). Article Title: Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia. Article Snippet: Numerous molecules enable the handling of glutamate that is destined for neurotransmitter release, including transporters, receptors and glutamatergic enzymes.. Previous work in our lab has shown altered levels of transcript expression of excitatory amino acid transporters and a vesicular glutamate transporter in the thalamus in schizophrenia.. These changes suggest that molecules that facilitate the release and reuptake of glutamate may be abnormal in schizophrenia. |